Cyhalofop-butyl is an aryloxyphenoxypropionic acid herbicide that is highly safe for rice and has good systemic conductivity. It inhibits the growth of weeds by inhibiting acetyl-CoA carboxylase (ACCase), and has a good control effect on weeds such as rice sedge and sorghum, and has a higher market share in rice field herbicides. Caused the attention of the majority of pesticide companies. The original drug of cyhalofoprin has been officially registered for protection, and many companies are working on the development and registration of this product.

The development and registration of cyhalofoprin in pesticide companies can be divided into two directions: First, attention should be paid to the registration of compound products of cyhalofop-butyl ester and other herbicides to expand the spectrum of killing and delay the emergence and development of resistance. To extend the shelf life of the product; second, to lay out the product on a single dose.

According to the Ministry of Agriculture No. 946 Announcement: pesticide products with the same active ingredients and dosage forms (including the same proportion of mixed preparation products), the active ingredient content should not be set to more than 5 gradients; emulsifiable concentrates, microemulsions, wettable powders The content of the active ingredient of the product shall not be lower than the active ingredient content of the approved production or registered products (including the compounded products of the same ratio); the pesticide products with the active ingredient content ≥10% (or 100 g/L) (including the same The proportion of the active ingredient content of the compounded preparations should not be less than 5% or 50 g/L.

At present, the registered dosage forms of cyhalofoprin in China mainly include: dispersible oil suspensions, suspending agents, water emulsions, microemulsions, wettable powders and emulsifiable concentrates.

Pesticide companies that are in the process of registering dispersible oil suspensions, emulsifiable concentrates and water emulsions should pay attention to the content gradient of cyhalofoprin. At present, the dosage levels of single-agent products of these dosage forms are more, which are close to the relevant provisions of five content gradients. In particular, when applying for the temporary registration of these single-dose products, it is especially important to pay attention to whether the products that have been temporarily registered have been officially registered, so as not to be preemptively registered by the opponent.

(1) Dispersible oil suspension agent

The single-agent content gradient of the ceflonide dispersible oil suspension agent that has been officially registered in China includes: 10%, 15%, 20%, and pesticide companies have obtained temporary registrations of 30% and 40%.

(2) emulsifiable concentrate

The content of the single-agent content of cyhalofoprin emulsifiable concentrate that has been officially registered in China includes four: 10% (or 100 g/L), 15%, 20%, 30%; in July 2016, Anhui Meilan Agricultural Development Co., Ltd. The company obtained a temporary registration of 25% cyhalofop-butyl emulsifiable concentrate.

(3) water emulsion

The concentration of a single dose of cyhalofoprin aqueous emulsion that has been officially registered in China includes four: 10% (or 100 g/L), 15%, 20%, 25%.

Therefore, pesticide companies should pay attention to the changes in the registration status of these content gradients when registering a new single dose of cyhalofoprin dosage form, especially pay attention to the change of temporary registration status, so as to avoid the content gradient not complying with relevant regulations in the registration process. Was rejected. (Huisheng pesticide registration agent)